HIF-1 은 Hypoxia 에 반응해서 glycolysis 을 촉진하고 OXPHOS 를 감소시키는데
HIF-1 은 Hypoxia 뿐만아니라 Hormone 과 growth factor 에도 반응해서
glycolysis 을 촉진하고 OXPHOS 를 감소시킨다
전략 -
Of note, the HIF pathway is also responsive to non-hypoxic stimuli such as hormones and growth factors.
-후략
전략 -
The paramount importance of HIF-1 stems from its ability to singlehandedly coordinate a number of genes encoding key components of metabolic adaptation in cancer cells [77], [87]. HIF regulates the balance between glycolytic and oxidative metabolism, tailoring the specific needs of rapidly growing cancer cells in a microenvironment that bears much similarity to the anaerobic world of early eukaryotic ancestors. HIF-1 induces glucose transporters (e.g., GLUT1 and GLUT3) and activates key glycolytic enzymes (e.g., hexokinase II), while it diverts pyruvate from breakdown in the TCA cycle by activating pyruvate dehydrogenase kinase 1 (PDK1) and hence inactivating PDH. HIF-1 also activates LDH and MCT4, facilitating the production of lactate from pyruvate and its transport out of the cell
-후략
위 자료를 보면 Hyoxia 상태가 아니래도 hormones and growth factors 에 자극받아서
HIF-1 가 활성화되면 glycolysis 을 촉진하고 OXPHOS 를 감소시켜서
growth 에 도움되는 metabolism 으로 변화될수 있다.
aerobic glycolysis 가 가능한 근거가된다.
과다한 육식을 통해서 hormones and growth factors 의 증가로
growth 에 도움되는 metabolism 으로 변화될수 있다.
육식이 종양의 원인이 될수 있는 근거다
참고자료 Mitochondrial uncoupling in cancer cells: Liabilities and opportunities - ScienceDirect