HIF-1 은  Hypoxia 에 반응해서  glycolysis 을 촉진하고 OXPHOS 를  감소시키는데


HIF-1 은  Hypoxia 뿐만아니라   Hormone 과 growth  factor 에도  반응해서  


glycolysis 을 촉진하고 OXPHOS 를  감소시킨다



전략 - 


Of note, the HIF pathway is also responsive to non-hypoxic stimuli such as hormones and growth factors.  


-후략 


전략 -


The paramount importance of HIF-1 stems from its ability to singlehandedly coordinate a number of genes encoding key components of metabolic adaptation in cancer cells [77], [87]. HIF regulates the balance between glycolytic and oxidative metabolism, tailoring the specific needs of rapidly growing cancer cells in a microenvironment that bears much similarity to the anaerobic world of early eukaryotic ancestors. HIF-1 induces glucose transporters (e.g., GLUT1 and GLUT3) and activates key glycolytic enzymes (e.g., hexokinase II), while it diverts pyruvate from breakdown in the TCA cycle by activating pyruvate dehydrogenase kinase 1 (PDK1) and hence inactivating PDH. HIF-1 also activates LDH and MCT4, facilitating the production of lactate from pyruvate and its transport out of the cell


-후략



위 자료를 보면  Hyoxia  상태가  아니래도   hormones and growth factors  에   자극받아서 


HIF-1 가 활성화되면  glycolysis 을 촉진하고 OXPHOS 를  감소시켜서


growth 에 도움되는    metabolism 으로  변화될수 있다.


aerobic glycolysis 가 가능한  근거가된다. 


과다한  육식을  통해서    hormones and growth factors  의  증가로 


growth 에 도움되는    metabolism 으로  변화될수 있다.  


육식이  종양의 원인이 될수 있는 근거다



참고자료  Mitochondrial uncoupling in cancer cells: Liabilities and opportunities - ScienceDirect